• Medical Research Institute - Sri Lanka

    The premier medical research institute in Sri Lanka
  • Medical Research Institute - Sri Lanka

    The premier medical research institute in Sri Lanka
  • Medical Research Institute - Sri Lanka

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Lilani Karunanayake

Dr Lilani Karunanayake,  M.B.B.S., Pg Dip (Med. Microbiology), MD 
Consultant Clinical Microbiologist
Medical Research Institute


Recent Awards:
1. National Health Research Symposium 4th – 5th December, 2017 – 2nd Place for Oral Presentation!( joint paper by Dr Lilani Karunanayake , Consultant Microbiologist, MRI and Presented by Dr Panduka Karunanayake , Senior Lecturer Faculty of Medicine, Colombo ) . Title :First report on Human Brucellosis in Sri Lanka. Research collaboration: Medical Research Institute and Department of Clinical Medicine, University of Colombo.
2. President’s Award for Scientific Publications – 2017, 2018
3.First place oral presentations in the Annual Scientific sessions Sri Lanka College of Microbiologists, September 2017.
Title: A multicenter study to determine the prevalence and the associated factors of New Delhi Metallo-Betalactamase-1 (NDM-1) strains among gram negative bacilli in clinical isolates

Publications Click here for (Research Gate)




  1. Karunanayake L.,Waniganayake Y., Gunawardena K.D.N., Padmaraja D.S.A., Peter D., Jayasekera R., Karunanayake P. Use of Silicon nanoparticle surface coating in infection control: Experience in a tropical healthcare setting. In, infection Disease & Health, Elsevier (2019) 24, 201e207. © 2019 Australasian College for Infection Prevention and Control DOI: https://doi.org/10.1016/j.idh.2019.06.006
  2. Karunanayake L. Karunanayake P., Rathnayaka S., Senarath U., Ranbanda J.M., Kothalawala M. Seroprevalence and associated risk factors of human Brucella infection in selected provinces in Sri Lanka. Brief Report. In Ceylon Medical Journal 2019; 64: 25-29 DOI: http://doi.org/10.4038/cmj.v64i1.8824
  3. Herath Nalaka, Uluwattage Wimalasiri, WeliwitiyaTheshanthi, Karunanayake Lilani, Lekamwasam Sarath, Ratnatunga Neelakanthi, Karunanayake Panduka, Wickramasinghe Sugeesha, Patabendi Sanjitha, Senaviratne Suranjith, and Agampodi Suneth. Sequel and therapeutic modalities of leptospirosis associated severe pulmonary haemorrhagic syndrome (SPHS); a Sri Lankan experience. In BMC Infectious Diseases (2019) 19:451 https://doi.org/10.1186/s12879-019-4094-0
  4. WAMP Samaranayake1, L Karunanayake, CGUA Patabendige. Characteristics of community acquired and hospital acquired methicillin resistant Staphylococcus aureus isolates in the National Hospital of Sri Lanka. Research Article. Sri Lankan Journal of Infectious Diseases 2019 Vol.9 (1)24-31 DOI: http://dx.doi.org/10.4038/sljid.v9i1.8229
  5. Galappaththi J., Chandrasiri ans., Marasinghe MAAN, Caldera TSKRD, Karunanayake L, Sajeewan R. Corynebacterium Diphtheriae bacteraemia in a patient undergoing regular haemodialysis. In The bulletin of the Sri Lanka College of Microbiologists Vol 16 August 2018, ISSN 1391-930X p. 109-111.
  6. Fernando N., De Silva R., Handunetti S., Karunanayake L. et al. Effects of antimicrobial agents on inflammatory cytokines in acute leptospirosis. Antimicrobial Agents and Chemotherapy 62(5): e02312-17 May 2018 DOI: 10.1128/AAC.02312-17
  7. Amarasinghe N., Muthulingam A., Jayamanne BDW., Sadikeen A., Fernando A., Rajapaksha.Y., Gunasekera K., Karunanayake L. Bacterial profile and antibiotic susceptibility of adult lower respiratory tract infections in Colombo, Sri Lanka. Journal of Health and Social Sciences 3(1)March 2018. DOI: 10.19204/2018/bctr3
  8. Karunanayake L., Harischandra P., Rambukwella U.B, Hapuarachchi C.T., Tshokey T. Post-transplant Urinary Tract Infections and Surgical Site Infections among Renal Transplant Recipients in a Transplant Unit in Sri Lanka. Indian Journal of Transplantation 2017;11(2)p31-34
  9. Perera WPDP, Karunarathne GKD, Karunanayake L., Weerasekera KP., Morawakkorala RN., Liyanarachci MS. Endocarditis due to Corynebacterium diphtheriae in a child. The Bulletin of the Sri Lanka college of Microbiologists Annual Scientific Sessions 31st August and 1st September, 2017, Colombo. Vol 15:(1) p74-75
  10. Karunanayake L, Karunanayake P, Perera KCR, Senarath U, Gunarathna HDNT, Peter D. Demographic, Clinical and Bacteriological characteristics of Human Leptospirosis in Sri Lanka: A retrospective analysis. In: J Bacteriol Mycol, July, 2016:3(2)
  11. Rajapakse S, Weeratunga P, Niloofa R, Fernando N, de Silva NL, Rodrigo C, Maduranga S, Nandasiri N, Premawansa S, Karunanayake L, de Silva HJ, Handunnetti S. A Diagnostic Scoring Model for Leptospirosis in Resource Limited Settings. In: PLOS Neglected Tropical Diseases June 22, 2016 p 1-10 DOI:10.1371/journal.pntd.0004513
  12. NP Senanayake, V Thevanesam, L Karunanayake, An outbreak of Pantoea agglomerans infection in the neonatal intensive care unit at Teaching Hospital, Kandy, Sri Lanka. In: Sri Lanka Journal of Child Health, 2016;45
  13. YC Waniganayake, UA Wijetunga, L Karunanayake, R Abeysinghe, Successful containment of a nosocomial outbreak of Burkholderia cepacia in a special care baby unit of a base hospital in Sri Lanka. In, Antimicrobial Resistance and Infection Control 2015, 4(Suppl 1):p264
  14. Senaka Rajapakse, Praveen Weeratunga, M. J. Roshan Niloofa, Narmada Fernandob, Chathuraka Rodrigo, Sachith Maduranga, Nipun Lakshitha Fernando, H. Janaka de Silva, Lilani Karunanayake and Shiroma Handunnetti (2015) Clinical and laboratory associations of severity in a Sri Lankan cohort of patients with serologically confirmed leptospirosis: a prospective study In Transactions of the Royal Society of Tropical Medicine and Hygiene, 2015;109:p710–716
  15. Roshan Niloofa, Narmada Fernando, Nipun Lakshitha de Silva, Lilani Karunanayake, Hasith Wickramasinghe, Nandana Dikmadugoda, Gayani Premawansa, Rajitha Wickramasinghe, H. Janaka de Silva, Sunil Premawansa, Senaka Rajapakse, Shiroma Handunnetti (2015) Diagnosis of Leptospirosis: Comparison between Microscopic Agglutination Test, IgM-ELISA and IgM Rapid Immunochromatography Test. PLOS ONE | DOI:10.1371/journal.pone.0129236 June 18, 2015
  16. Senanayake NP, Karunanayake L Outbreak of bloodstream infection with extended-spectrum ß-lactamase-producing Klebsiella pneumoniae at a Teaching Hospital In Journal of Pediatricians Society, September-December, 2014:Vol:34; Issue 3
  1. Nipun Lakshitha De Silva, MJR Niloofa, Narmada Fernando, Lilani Karunanayake, Chaturaka Rodrigo, Janaka De Silva, Sunil Premawansa, Shiroma M Handunnetti, Senaka Rajapakse (2014) Changes in full blood count parameters in leptospirosis: a prospective study. Short Report In: International Archives of Medicine 2014, 7:31 http://www.intarchmed.com/content/7/1/31
  2. Manju Bala, Monika Kakran, Vikram Singh, Seema Sood, V Ramesh Members of the WHO GASP SEAR Network (2013) Monitoring antimicrobial resistance in Neisseria gonorrhoeae in selected countries of the WHO South-East Asia Region between 2009 and 2012: a retrospective analysis In Sexually Transmitted Infections 2013;89:iv28–iv3
  3. Agampodi SBKarunarathna DJayathilala NRathnayaka HAgampodi TCKarunanayake L. Outbreak of leptospirosis after white-water rafting: sign of a shift from rural to recreational leptospirosis in Sri Lanka?. In: Epidemiology and Infection 2013:142 (4);p843-846. doi.org/10.1017/S0950268813001465
  4. Chandrasiri P., Elwitigala J.P., Nanayakkara G., Chandrasiri S., Patabendige G., Karunanayake L., Perera J., Somaratne P., Jayathilleke K. A multi centre laboratory study of Gram negative bacterial blood stream infections in Sri Lanka In Ceylon Medical Journal 2013; 58: 56-61
  5. Karunanayake Lilani, Tennakoon C. Optochin-resistant Streptococcus pneumoniae. To the Editors: Ceylon Medical Journal 2011; 56: 41-42
  6. Karunanayake Lilani, Dayananda Bandara, Dunusinghe P. Fatal meningitis in a child due to a multi-drug resistant Streptococcus pneumoniae. Case Report In: Ceylon Medical Journal 2009: Vol.52(1) 32-33. doi: 10.4038/cmj.v52i1.1049
  7. Patabendige C.G.U.A, Chandrasiri N.S., Karunanayake L. I., Karunaratne G.K.D., Somaratne P., Elwitigala J.P, Chandrasiri  P.Antimicrobial resistance in resource-poor settings – Sri Lankan experience in WHO Regional Health forum, special issue on Antimicrobial Resistance in South-East Asia, 15;1;2011
  8. Parry CM, Karunanayake Lilani, Coulter JBS, Beeching NJ (2006).  Test for quinolone resistance in typhoid fever.  British Medical Journal 333: 260
  9. Karunanayake Lilani, Atukorale SD (2004).  Enteric fever caused by Salmonella isolates with decreased susceptibility to ciprofloxacin. Ceylon Medical Journal 49: 137
  10. Karunanayake L.I. (2002). Microbiological characterization of genital Herpes at the Central STD clinic Colombo. MD thesis in Microbiology, PGIM, University of Colombo

Contributions to Books


  1. National Guideline on management of leptospirosis (2016), MoH: Chapter on ‘Laboratory Diagnosis’
  2. Empirical and prophylactic use of antimicrobials, National Guideline 2016, MoH: In the sub committee
  3. Biosafety Manual for Medical Laboratories, 2nd Edition SLCM 2014. In Editorial Board
  4. Handbook on National External Quality Assessment in Bacteriology, Medical Research Institute, Colombo 2013: In Editorial Board
  5. Global Action Plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae. World health Organization publication 2012: Acknowledgement
  6. Aetiological Agents, Antibiotic Susceptibility and Outcome of Septic/Bacteraemic Patients in Selected Sri Lankan health Institutions Surveillance, Report by ARSP Working Committee, 2011
  7. Laboratory Manual in Microbiology, Sri Lanka College of Microbiologists, MoH 2011
  8. Ministry of Health care and Nutrition National Guidelines – Microbiology, Chapter on ‘Patient care Device management – Prevention of urinary catheter associated UTI’ Ministry of Health and HSDP 2007
  9. Influenza virus: changing pattern. Avian Influenza 2006 published by Health Education unit, Teaching Hospital, Peradeniya – Chapter on ‘Laboratory diagnosis’