• Medical Research Institute - Sri Lanka

  • Medical Research Institute - Sri Lanka

  • Medical Research Institute - Sri Lanka

    Sky View

Research & Training Activities

Research & Training Animal Center

2017

Research communications for the year 2017 (January –December) – Full paper articles in peer Reviewed Journals

1)       Ingestion of dug well water from an area with high prevalence of chronic kidney disease of unknown aetiology (CKDu) and development of kidney and liver lesions in rats. Ceylon Medical Journal.2017: 62(1)20-34.

M.G.Thammitiyagodage1, M.M.gunatillaka1, N.Ekanayaka1, C.Rathnayake1, N.U.Horadagoda2, R Jayathissa1,U.K.Gunaratne3, W.G.Kumara1 , P Abeynayake2.

1. Medical Research Institute, Dr Danister de Silva Mawatha, Colombo 8.

2. Faculty of Veterinary Medicine and Animal Science, University of Peradeniya.

3. Regional Epidemiology Unit, Ministry of Health, Pollonnaruwa.

1. The gastroprotective effect of ethyl acetate fraction of hot water extract of Trichosanthes cucumerina Linn and its underlying mechanisms (Ramani Karunakaran, M. Ira Thabrew, G. Mayuri Thammitiyagodage, B. Prasanna Galhena and L.D.A. Menuka Arawwawala )Full article link

3)      Serum antibody titres for Leptospira and its association to the immunization and rearing pattern in a sample of dogs from suburbs of Colombo – A preliminary study.

M.G.Thammitiyagodage1, Somaratne P1, M.A.Roshan Priyantha2 and K.C.R.Perera1.

1. Medical research Institute, Dr Danister de Silva Mawatha, Colombo 8

2. Veterinary Research Institute, Gannoruwa, Peradeniya.

Research communications for the year 2017 (January –December) – Oral Presentation.

1. Comparison of Micro Albumin/Creatinine ratios in Wistar rats that ingested water from high and low disease prevalent areas for Chronic Kidney Disease of Unknown etiology (CKDu) from North Central Provinve (NCP) and low disease prevalent Colombo.

. M.G.Thammitiyagodage, N.R.de Silva, Karunakaran R, Kumara W.G.S.S, M.M.Gunatillake, B.P.Galhena, M.I.Thabrew.Proccedings of the 4th Annual Scientific Sessions of the Sri lanka Association for Laboratory Animal Science.23rd -24th January 2017.


2013
1. A PRELIMINARY  STUDY  OF  THE  SEROPREVALENCE  OF LEPTOSPIROSIS  IN  DOMESTIC DOGS IN SUBURBS  OF COLOMBO, SRI LANKA.
M.G.Thammitiyagodage(1), P. Somaratne(1), K.C.R  Perera(1) and M. A. Roshan Priyantha(2), 
1. Medical Research Institute, No 527, Dr. Danister de Silva Mawatha, Colombo 8,  Sri Lanka.
2. Veterinary Research Institute, P.O. Box 28, Gannoruwa,  Peradeniya.
Click here for Abstract

Upto 2012
Dr. Sharmini Jayasekera, veterinary surgeon who was trained under JICA cooperation
initiated the work in collaboration with Japanese team to establish the animal centre. She
worked as the Head of the Section since 1989 to 2010 and she pioneered the research
activities in the animal centre, MRI.

(01)Thabrew MI, Samarawickrema N, Chandrasena LG, Jayasekera S.
Effect of oral supplementation with vitamin E on the oxido-reductive status of red
blood cells in normal mice and mice subject to oxidative stress by chronic
administration of Adriamycin. Annals of Clinical Biochemistry 1999, 36:216-220
Received presidential awards  1999

(02)Thammitiyagodage MG, Munasinghe TMJ, Peiris H.
Making Wistar rat’s hypercholesterolaemic by feeding a diet containing 0.25%
cholesterol and 5% butter fat.
Sri Lanka Veterinary Journal (46) (1999). (1); 13-14.

(03)Thabrew MI, Samarawickrema N, Chandrasena LG, Jayasekera S.
Protection by garlic against Adriamycin induced alteration in the oxido-reductive
status of mouse red blood cells. Phototherapy Research 14, 215-217(2000)

(04)Samaranayake MDP, Wickramasighe SMDN, Angunawela P,
Jayasekera S, Seneviratne AGDH, Iwai S, Fukushima S.
Inhibition of chemically induced liver carcinogenesis in Wistar rats by garlic
(Allium sativum). Phytotherapy Research14, 561-567 (2000)
Received presidential awards 2000

(05)Jayasekera S, Arseculeratne SN, Atapattu DN, Kumarasiri R,
Tilakaratne WM.
Cell-mediated immune responses (CMIR) to Rhinosporidium seeberi in mice.
Mycopathologia152; 69-79 (2000)

(06)Ariyasena DD, Janz ER, Jayasekera S, Abeysekera AM.
Inhibitory effect of bitter principle of Palmyra (Borassus flabellifer L) fruit pulp
on the growth of mice: evidence using bitter and non bitter fruit pulp.
Journal of the Science of Food and Agriculture 80:1763-1766 (2000)

(07)Ekanayake S, Janz ER, Abeysekera AM, Jayasekera S.
Effect of Canavalia gladiata seed meal on impregnated mice
Journal of Science, Eastern University of Sri Lanka (2001) Vol.2No.1, p1-8
Received presidential awards 2001

(08)Iddamaldeniya SS, Wickramasinghe SMD, Thabrew MI, Rathnatunga
N, Thammitiyagodage MG.
Protection Against Di- Ethyl Nitrosamine Induced Hepatocarcinogenesis by
Indigenous remedies.
Journal of Carcinogensis 2003: 2: 6: 9 (18 the Oct 2003)

(09)Vindica Sumudini KA, Janz ER, Jayasekera S, Wickramasighe
SMDN. The Neurotoxic effect of (Borassus Flabellifer) flour re-visited
Nutritional Journal of Food and Nutrition volume 55, number 8 (December 2004)
607-614

(10)Rajapakshe RPAS, Perera WSR, Ihalamulla RL, Weerasena KH, Jayasinghe
S, Sajeewani HBR, Thammitiyagodage MG and Karunaweera ND.
Study of dirofilariasis in selected areas in the western province.
Ceylon Medical Journal Vol. 50 No 2 June 2005.

(11)Iddamaldeniya SS, Wickramasinghe SMD, Thabrew MI, Rathnatunga
N, Thammitiyagodage MG.
Toxicity study of a decoction comprised of Nigella sativa, Hemidesmas indicus
and Smilax glabra.  Ceylon Medical Journal Vol. 50 No 2 June 2005.

(12)Iddamaldeniya SS, Thabrew MI,  Wickramasinghe SMD, Rathnatunga
N.Thammitiyagodage MG.
A long – term investigation of the anti hepatocarcinogenic potential of an
indigenous medicine comprised of Nigella sativa, Hemidesmus indicus, and
Smilax glabra Journal of Carcinogenesis 2006,5:11(9th May 2006)

(13)AthiththanLV , JayaratneSD,  Peiris H, and  Jayasekera S.
The effect of milk protein and curd on serum Angiotensin Converting Enzyme
activity and lipid profile.
Journal of National Science Foundation Sri Lanka 2009 37 (3) 203

(14)Thammitiyagodage MG, Chandrasiri P, Kumari Dissanayake HMR
Puvandiran S and Jayathunga S.
Identification of Serovas of Leptospira among Buffaloes and Buffaloe Farmers
In Homagama Veterinary Division in Sri Lanka.  Sri Lanka Veterinary journal (SLVJ) 2007- 54-55 (A) pp7-10.


Communications (Oral presentations)

(01)Samaranayake MDP, Wickramasighe SMDN, Jayasekera S.
Effect of garlic on diet induced hypercholesterolemia in Wistar rats.
Annual Academic sessions 1998, University of Sri Jayewardenepura.

(02)Samaranayake MDP, Wickramasighe SMDN, Jayasekera S.
Effect of cholesterol-enriched diets on blood cholesterol levels in Wistar rats, 54th
Annual session Sri Lanka Association for the Advancement of science. (1998)

(03)Samaranayake MDP, Wickramasighe SMDN, Angunawela P, Jayasekera
S, Seneviratne AGDH, Iwai S, Fukushima S.
Inhibition of hepato-carcinogenisis in Wistar rats by garlic (Allium sativum),
112Th Anniversary Academic Sessions, Sri Lanka Medical Association (1999)

(04)Samaranayake MDP, Wickramasighe SMDN, Jayasekera S.
Reduction of risk of liver cancer by garlic (Allium sativum) in
hypercholesterolaemic Wistar rats. Chemistry in Sri Lanka (1999)

(05)Goonaratne PS, Janz ER, Illeperuma N, Jayasekera S.
Determination of L-Dopa In Mucuna utilis and feeding trials in ICR mice.
Chemistry in Sri Lanka (1999)

(06)Ekanayake S, Janz ER, Abeysekera AM, Jayasekera S.
Some anti nutritional factors of Canavalia gladiata. Chemistry in Sri Lanka
(1999)

(07)Ariyasena DD, Janz ER, Jayasekera S, Abeysekera AM.
Evidence to link the bitter principle of Palmyra (s) fruit
pulp with the inhibition of weight gain in ICR mice. Chemistry in Sri Lanka
(2000)

(08)Thammitiyagodage MG, Colambage G, Weerasinghe IS, Jayasekera
S, Junaid M. (2000).
An investigation of Trypanasomiasis in the animal
population of Chena -Kudiruppu area in Kalmunai and possibility of zoonotic transmission.
52 nd Annual Convention of Sri Lanka Veterinary Association and Asian
Regional Meeting of the Commonwealth Veterinary Association.

(09)Thammitiyagodage MG, Thabrew MI, Munasinghe
TMJ, Kumara WGSS (2001).
An investigation of possible lipid lowering properties of Alliums Porum (Leek) in
Wister rats.
53 rd annual convention and scientific session of Sri Lanka Veterinary
Association

(10) Iddamaldeniya SS, Wickremesinghe SMDN, Thabrew I, Ratnatunga
N,Thammitiyagodage MG, Jayathilake N, Ramadasa SS. (2002).
Inhibition of chemically inducible Glutathione. S Transferase placental form
(GST- P) By Plant extracts.
Annual Academic Sessions. The collage of Pathologist of Sri Lanka.

(11)Iddamaldeniya SS, Wickremesinghe SMDN, Thabrew I, Ratnatunga
N, Thammitiyagodage MG and Jayathilake N.
Protection against diethylnitrosoamine (DEN) induced hepatocarcinogenisis by an
Indigenous medicine comprised of Nigella sataiva, Smilax glabra and
Hemidesmus Indicus. World Ayurveda Congress 2002

(12)Subashini RM, Thammitiyagodage MG, Jayasekera S. and
Kumara WGGS (2002).
Detection of possible hypoglycaemic activity and toxic effect of `Cogent db ‘
on normoglycaemic Wistar rats. Sri Lanka Association for the Advancement of
Science (SLAAS).Proceedings of the 58 th annual Session, part 1 –
Abstract of Presentations.

(13)Iddamaldeniya SS, Wickramasinghe SMDN, Thabrew MI, Ratnatunge
Thammitiyagodage MG. and Jayathilake N.
Protection against diethylnitrosamine (DEN) induced hepatocarcinogenesis in rats
by an indigenous herbal remedy.
Sri Lanka Association for the Advancement of Science (SLAAS).
Proceedings of the 58 th annual Session, part 1 –Abstract of Presentations.

(14)Thammitiyagodage MG, Jayasekera S, Galagoda GCS, Rashid
L,Ekanayake N, Bandumala KAP.
Investigation of sudden deaths among crows (Corvus splendens) in Colombo
municipality area.
55th Annual Convention and Scientific Sessions of Sri Lanka Veterinary
Association 2003.

(15) Iddamaldeniya SS, Thabrew MI, Wickramasinghe SMDN, Rathnatunga
N, Thammitiyagodage MG.
Traditional remedy comprised of Nigella sativa seeds, Hemidesmes indicus root
And Smilax glabra rhizomes with possible anti hepatocarsinogenic potential.
56thAnnual Convention of the Sri Lanka Veterinary Association 2004.

(16)Thammitiyagodage MG, Chandrasiri P, Dissanayake HMRK,
Puwanendran S. and Jayathunge S.
An investigation of the relationship between Leptospirosis in humans and in
buffalo of Homagama veterinary division.
56thAnnual Convention of the Sri Lanka Veterinary Association 2004.

(17) Rajapakshe RPAS, Perera WSR, Ihalamulla RL, Weerasena KH,
Jayasinghe S, Sajeewani HBR,Thammitiyagodage MG &KarunaweeraND.
Study of human and canine dirofilariasis in a selected area in the western
province.
The Annual Academic Sessions Sri Lanka College of microbiologists 2004

(18) LankanandaBD, ThammitiyagodageMG, KumaraWGSS, Weerasinghe GAK.
Effect of aqueous and methanolic bark extract of Canarium zelanicum (family: Burseracae) in Plasmodium yoelii murine malarial model.

(19) Galhena BP, ThabrewMI, Thammitiyagodage MG.
Investigation of the antioxidant activity of a herbal decoction with anti-
Carcinogenic properties.
Sri Lanka Association for Advancement of Science
Proceedings of the 63rd annual Sessions-2007.Part 1-Abstracts

(20) Athiththan LV, Peiris H,  Jayasekera S and  Jayaratne SD.
Effect of whey protein on angiotensin converting enzyme activity and lipid
profile of wistar rats
Proceedings of the 63rd annual Sessions-2007.Part 1-Abstracts p10
Sri Lanka Association for Advancement of Science
Awarded the 1st prize for best oral communication

(21) Athiththan, LV, Peirs, H, Jayasekera, S and Jayaratne SD. A study on the
effect of curd and casein on serum angiotensin converting enzyme activity and
lipid profile in male Wistar rats. 59th Annual Convention and Scientific Sessions
of the Sri Lanka Veterinary Association. 2007 (17).

(22) Thammitiyagoda MG,Gunatilake  MM, Jayasekera S, Gunaratne UKSC, Kumara WGSS.
and Abeynayake . Effect of bore well water obtained from villages in the(NCP) with high
prevalance of chronic kidney disease (CKD) in rats. Sri Lanka Association for Advancement of Science
Proceedings of the 65th annual Sessions-2009. Part 1-Abstracts

(23) Thammitiyagodage MG, Gunatillaka MM, Jayasekera S , Jayathissa R,
GunarathneUKSC, Jayamanna S, Kumara WGSS and AnenayakeP.
Quetionnaire Based Study to Develop a Laboratory Animal Model to Identify
The Etiology of Chronic Kidney Disease of Unknown Etiology (CKDu) in North
Central Province of Sri Lanka.
61st Annual Convension of the Sri Lanka Veterinary Association.27th March
2009.

(24) Thammitiyagodage MG, Gunathilaka MM, Jayasekera S,
Udayangani DIE,  Gunarathne UKSC, AbenayakeP.
Is there a relationship between diminished GFR, elevated liver enzymes levels &
Chronic Kidney Disease in North Central Province of Sri lanka.
3rd Svastha International Ayurveda Conference 2nd to 3rd January 2010.

(25) Thammitiyagodage MG, Gunatilake MM, Jayasekera S, Horadagoda N,
JayathilakeMMU, GunarathneUKSC, Ekanayake N, Abenayake P.
Periglomerular and Peritubular Non Suppurative Interstitial Nephritis In Wistar
Rats Given Bore Well Water From North central Province (NCP) of Sri Lanka.
10th South East ASIA Regional Scientific Meeting of The International
Epidemiological Association 23rd-26th May 2010.

(26) Thammityagodage MG.
Social Approach to Bioethics in Animal Experiment in Sri Lanka, Social
Scientific Approach to Bio Ethics Conference,London,5th to 7th January 2011.

(27) Thammitiyagodage MG, Rathnayake C, Gunatillaka MM, Ekanayaka N, JayatissaR, GunarathneUKSC ,  Jayathilake WMMU.
Histopathological changes in liver and renal tissues in Wistar rats given bore well water from CKDu endemic areas in North Central Province
125th Anniversary International Medical Congress of Sri Lanka Medical Association(2012).
S.Ramachandran award for best communication in nephrology

(28) Tharaka Prasad, Thammitiyagodage MG, Karunakaran R, Kothalawala H, Lilani Karunanayake and Deepal Gajadeera.
Isolation of Newcastle disease virus in the pelagic bird, Sooty Tern (Onychoprion fuscatus) in Sri Lanka.
Abstract of 64th Annual convention of the Sri Lanka Veterinary Association (2012)

(29) Rodrigo WWP, Thammitiyagodage MG, Dasanayake RS, Weerasena OVDSJ and Karunanayake EH.
Production of polyclonal antibodies against recombinant uncharacterized protein of Setaria digitata using New Zealand White rabbits. Proceedings of the 6th biennial scientific sessions of Allegy and Immunology Society of Sri Lanka 2012.

(30) Rodrigo WWP, Dasanayake RS, Karunanayake EH, Weerasena OVDSJ and Thammitiyagodage MG.
Production of antiserum for uncharacterized protein of Setaria digitata using New Zealand White rabbits.
Proceedings of 5th Annual Scientific sessions of Institute of Bio chemistry, Molecular Biology, and Biotechnolgy (IBMBB) 2012.

(31) Thammitiyagodage MG, Karunakaran R, Pimburage RMS, Jayasinghe DN. Prolonged Swine anaesthesia without gaseous maintenance . Proceedings of 68th Annual scientific sessions Sri Lanka Association for Advancement of Science 2012.

(32) Thammitiyagodage MG, Gunatillaka MM, Ekanayaka N ,  Rathnayake C, Horadagoda NU, Jayatissa R, Kumara WGSS, Gunaratne UKSC.
Impact of the composition of  selected dug well water from North Central Province (NCP) in the development of interstitial nephritis, hepatocellular carcinoma  and hepatitis in Wistar rats.
Scientific sessions MRI Research day 2012.
Awarded 2nd prize for oral communication

(33)  Thammitiyagodage MG, Somaratne P, Perera KCR, Roshan Priyantha MA.
A preliminary study of the seroprevalence of Leptospirosis in domestic dogs in suburbs of Colombo Sri Abstracts of  65th Annual Convention of Sri Lanka Veterinary association,2013


Poster Presentations

(01)Obeysekera N, Thammitiyagodage MG.
Sublingual Edema of a Dog
53thAnnual Convention of the Sri Lanka Veterinary Association 2001.

(02)Ekanayake S, Jayasekera S, Thammitiyagodage MG. and Kumara WGSS.
A study of the estrus cycle and pregnancy of ICR mice bred and maintained at
the MRI.
Abstract of Papers 4th Research Session, Faculty of Graduate Studies, University
of Sri Jayawardenepura.

(3) Iddamaldeniya SS, Thabrew MI, Wickramasinghe SMDN, Rathnatunga
N, Thammitiyagodage MG.
Traditional remedy with possible antihepatocarcinogenic potential.
117th Annual Academic Sessions Sri Lanka Medical Association 2004

(4) Thammitiyagodage MG,  Jayasekera S,  Obayasekera N.
Ethical and legal aspects of animal experiments in Sri Lanka.
13th congress on Alternatives to Animal Testing- University of Linz, Austria.
2006

(5) Thammitiyagodage MG, Somaratne P, Perera KCR, Karunakaran R.
Domestic canine vaccination patterns and methods of rearing them in suburban settings in Colombo, Sri Lanka.
Abstract of 3rd Rabies in Asia Conference (RIACON) 2011

(6) Karunakaran R, Thammitiyagpdage MG, Seneviratna RDeS,  KumaraWGSS,  LiyanageTK and Lilani Karunanayake.
Occurrence of Clostridium sordellii in sheep  at MRI.
Abstracts of 64th Annual convention of the Sri Lanka Veterinary Association(2012).

Skip to toolbar